内容简介
This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology.
The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
目录(40 chapters)
The Human Space Exploration Endeavour: A Personal View from Inside——Pages 3-5
Space Travel: A Personal View from Above——Pages 7-8
Entering a New Era of Holistic Research in Establishing Groundwork for Future Human Space Exploration: Perspectives from the ESA-Topical Team “Stress and Immunity” ——Pages 9-15
What Is Stress? ——Pages 19-42
Environmental Stress: Mitochondria as Targets and Stressors in Cellular Metabolism——Pages 43-70
The Impact of Everyday Stressors on the Immune System and Health——Pages 71-92
Neurobiological Mechanisms of Stress and Glucocorticoid Effects on Learning and Memory: Implications for Stress Disorders on Earth and in Space——Pages 95-122
The Autonomic Nervous System——Pages 123-143
Circadian Rhythm and Stress——Pages 145-179
Endocannabinoids, “New-Old” Mediators of Stress Homeostasis——Pages 181-204
Immune System in Space: General Introduction and Observations on Stress-Sensitive Regulations——Pages 205-220
Innate Immunity Under the Exposome of Space Flight——Pages 221-240
NK Cell Assessments: A 40-Years-Old History of Immune–Stress Interaction in Space with a Promising Future——Pages 241-257
Adaptive Immunity and Spaceflight——Pages 259-275
B-Cell Immunology in Space——Pages 277-286
Stress, Hypoxia, and Immune Responses——Pages 287-299
Cellular and Molecular Responses to Gravitational Force-Triggered Stress in Cells of the Immune System——Pages 301-325
Microbial Stress: Spaceflight-Induced Alterations in Microbial Virulence and Infectious Disease Risks for the Crew——Pages 327-355
Stress, Spaceflight, and Latent Herpes Virus Reactivation——Pages 357-372
Stress and Radiation Responsiveness——Pages 373-404
Considerations for Development and Application of Health Monitoring Tools in Space——Pages 407-420
Psychological Monitoring——Pages 421-432
Monitoring of Autonomic Activity by Cardiovascular Variability: How to Measure? ——Pages 433-449
Breath Gas Analysis——Pages 451-461
Monitoring the Microbial Burden in Manned Space Stations——Pages 463-475
Monitoring of Core Body Temperature in Humans——Pages 477-498
Flow Cytometry Methods to Monitor Immune Dysregulation Associated with Spaceflight——Pages 499-518
Assessment of Radiosensitivity and Biomonitoring of Exposure to Space Radiation——Pages 519-533
Analytical Approaches to the Quantitative Evaluation of Endocannabinoids and Glucocorticoids as Stress Markers: Growing Evidence for Hair Testing——Pages 535-552
Preventive and Therapeutic Strategies to Counter Immune System Dysfunctioning During Spaceflight——Pages 555-561
Psychological Countermeasures——Pages 563-575
Physical Countermeasures to Stress——Pages 577-592
Nutritional Countermeasures for Spaceflight-Related Stress——Pages 593-616
Microbiome and Immunity: A Critical Link for Long-Duration Space Exploration Missions——Pages 617-635
Pharmacological Countermeasures to Spaceflight-Induced Alterations of the Immune System——Pages 637-657
Platforms for Stress and Immune Research in Preparation for Long-Duration Space Exploration Missions——Pages 661-676
Mars500: The First Preparation of Long-Duration Space Exploration Missions—Results and Implications for a Holistic Stress and Immune Research Approach——Pages 677-692
Exploration Class Missions on Earth: Lessons Learnt from Life in Extreme Antarctic Isolation and Confinement——Pages 693-707
Moon, Mars and Beyond——Pages 709-733
Summary and Outlook——Pages 737-751
网址： https://www.springer.com/cn/book/9783030169954